ENISE's research activities act in synergy with the following laboratories: Laboratoire de Tribologie et Dynamique des Systèmes (LTDS), which is a Joint Research Unit with the French National Centre for Scientific Research: CNRS (UMR 5513), as well as with École Centrale de Lyon and École Nationale des Travaux Publics de l’État, and with Laboratoire d’Informatique et des Systèmes d’Information (LIRIS), a Joint Research Unit with CNRS (UMR 5205).
The lecturers and researchers of ENISE are also involved in the activities of the laboratory of excellence MANUTECH-SISE and are members of the economic interest group Equipement d’Excellence MANUTECH-USD, and of the group Equipement d’Excellence IVTV for the Engineering and Ageing of Human Tissue (Ingénierie et Vieillissement des Tissus Vivants) and of Institut Carnot Ingénierie also.